The brewery was established in 1839 by both nearby Czech-talking and German-talking residents in the Bohemian city of Plzeň as Bürgerbrauerei (residents' brewery, later meant Měšťanský pivovar in Czech). The main beer was brewed here in 1842 by Bavarian brewer Josef Groll. In 1859, "Pilsner Bier" was enlisted as a brand name at the nearby Chamber of Commerce and Trade.
In 1869, a contender was established as a business entity, later known as Gambrinus. In 1898 the German brand name Urquell and Czech brand name Prazdroj were made, to underline the case of being the more established, unique wellspring of Pilsner beer. In 1932 Měšťanský pivovar converged with Plzeňské aciové pivovary. In 1946, the brewery was nationalized under the name Plzeňské pivovary (Pilsen breweries).
After the fall of socialism in late 1989, the brewery was transformed into a public offer organization, then renamed in 1994 after the Czech name of their well-known beer, Plzeňský Prazdroj. In 1999, they began to converge with Pivovar Radegast a.s. what's more, Pivovar Velké Popovice a. s..
The brewery has been the biggest exporter of beer delivered in the Czech Republic since 2000 when creation outperformed that of Budějovický Budvar.