The brewery was founded in 1900 by Paul Cantillon, whose father was a brewer as well, and his wife, Marie Troch. As of 2011, the owner is Jean-Pierre van Roy, the fourth-generation brewer at Cantillon. Since its foundation, the only major change has been a shift to organic ingredients in 1999. Cantillon was one of more than one hundred operating breweries in Brussels at its foundation and was the only one to remain operational through the 2000s. In 2014, van Roy announced that the brewery would be acquiring more maturation space, effectively doubling production by 2016-17.